Abstract: Objective:To investigate the association among blood pressure variability,plasma von willebrand factor(vWF)and D-dimer levels in elderly patients with essential hypertension.Methods:One hundred cases whose age over 60 years with essential hypertension(hypertension group)and 100 cases of healthy elderly controls(control group)were randomly recruited into study.The blood pressure variability during 24 hours was monitored and plasma vWF and D-dimer levels were measured for each patient in both groups.The associations between blood pressure variability and plasma vWF and D-dimer levels were analyzed in each group respectively.Results:The blood pressure variability during 24 hours in hypertension group were significantly higher than that in control group(P0.01).The plasma vWF level in hypertension group was significantly higher than that in control group(P0.01).The plasma vWF level was positively correlated with 24 hours systolic blood pressure variability in hypertension group(P0.05).Conclusions:Blood pressure variability in hypertension patients with essential hypertension was increased obviously accompanied with the increase of plasma vWF level,which implying the potential impairment of vascular endothelium.