Abstract: Objective:To explore the curative effect influence of rehabilitation nursing with the core of multiple sensory stimulation onneonatal bilirubin encephalopathy.Methods:Seventy-four neonates with hypoxic-ischemic encephalopathy were randomly divided into control group( 35 cases) and observation group ( 39 cases).Patients in control group were nursed with routine nursing.Patients in observation group were nursed with rehabilitation nursing with the core of multiple sensory stimulation.The developmental quotient( DQ),psychomotor development index( PDI) and mental development index( MDI) of two groups were measured at 6,9 and 12 months before and after treatment.Results:DQ,PDI and MDI of two groups improved significantly at 6,9 and 12 months after treatment( P0.01).Compared with the control group,the DQ of the observation group were significant improvement at 6 and 12 months after treatment( P0.05 to P0.01),and the PDI and MDI were significant improvement at 6,9 and 12 months after treatment( P0.01).Conclusions:The rehabilitation nursing with the core of multiple sensory stimulation can effectively promote the recovery of cranial nerve,motor function and intellectual development of neonatal bilirubin encephalopathy.