HLA-DQB1等位基因多态性与宫颈癌的关联性

The correlation analysis between allele polymorphism of HLA-DQB1 and cervical cancer

摘要: 目的：探讨人类第6号染色体短臂HLA-DQB1基因多态性与中国广东汉族宫颈癌家系的关系。方法：采用基于DNA测序的分型方法对75个核心家系的DQB1基因型进行检测，并利用家系为基础的关联性检验进行数据分析。结果：DQB1*030302(P0.01)和DQB1*0602(P0.05)可能会增加宫颈癌的发病风险。结论：HLA-Ⅱ类基因上的部分等位基因可能是广东汉族人群宫颈癌的易感基因。DQB1*030302、DQB1*0602由杂合子父母优势传递给患病子女或者与正常同胞相比更容易传递给患者，它们与宫颈癌的发病相关。

Abstract: Objective: To investigate the correlations between allele polymorphism of HLA-DQB1 in the short arm of chromosome 6 and cervical cancer from Guangdong Han nationality family.Methods:The genotypes of HLA-DQB1 from 75 cervical cancer families were detected by polymerase chain reaction of sequencing based typing,which were analysed by family-based association test(FBAT).Results:FBAT showed that DQB1* 030302(P0.01) and DQB1* 0602(P0.05) might increase the onset risk of cervical cancer.Conclusions:The partial alleles in typeⅡ HLA gene may be the susceptible gene of cervical cancer in Guangdong Han population.The DQB1* 030302 and DQB1*0602 are associated with the pathogenesis of cervical cancer.