奥曲肽对人前列腺癌细胞生长周期的作用

Effect of octreotide on the growth cycle of human prostate cancer cell

摘要: 目的：探讨奥曲肽(OCT)作用下激素抵抗型前列腺癌细胞生长及周期的变化。方法：选择梯度浓度的OCT作用于人前列腺癌PC-3细胞株，观察浓度依赖性生长曲线;同时运用流式细胞术检测前列腺癌PC-3细胞周期在OCT作用下的变化。结果：随OCT浓度的递增前列腺癌PC-3细胞的生长逐步受到抑制，与对照组差异均有统计学意义(P0.05～P0.01)，OCT作用后前列腺癌细胞周期停滞G0/G1期。结论：OCT能够抑制前列腺癌PC-3细胞的生长，为激素抵抗型前列腺癌的治疗提供新思路。

Abstract: Objective: To explore the effects of octreotide(OCT) on the growth cycle of hormone-resiotant human prostate cancer cell.Methods:PC-3 cell line(human prostate cancer cell) was treated with gradient concentration of OCT,the growth curve of PC-3 cells was observed,and the growth cycle of PC-3 cell was detected by flow cytometry.Results:Concentration-dependent growth inhibition of octreotide was detected in the PC-3 cell line(P0.05 to P0.01).The growth cycle of PC-3 cell arrested in G0 / G1 phase after treatment with OCT.Conclusions:Octreotide can inhibit the growth of prostate cancer cell line,which provide a new method for treating hormone refractory prostate cancer.