Abstract: Objective: To investigate the pathogeny and relative factors of acute non-variceal upper gastrointestinal hemorrhage in aged people.Methods:The clinical data of 104 aged people with acute nonvariceal upper gastrointestinal hemorrhage diagnosed by gastroscope (observation group) were retrospectively analyzed,104 young and middle-aged people with acute nonvariceal upper gastrointestinal hemorrhage diagnosed by gastroscope were set as control group.The causes of disease,uncontrolled hemorrhagic incidence of peripheral circulatory failure,stay days,incentive,complications,the rebleeding rate(during hospital stay) and mortality of two groups were analyzed.Results:The peptic ulcer was the main causes of disease in two groups,their causes composition was not statistical significance(P0.05).Helicobacter pylori(Hp) infection and the application of non-steroidal anti-inflammatory drug were the main incentive in observation group,Hp infection and drinking were the main incentive in control group.Uncontrolled hemorrhagic incidence of peripheral circulatory failure,stay days,complications,the rebleeding rate and mortality of observtion group were higher than those in control group(P0.05 to P0.01).Conclusions:Clearing pathogeny and inducement as early as possible and taking reasonable treatment during the period of acute non-variceal upper gastrointestinal hemorrhage can reduce the mortality and rebleeding rate of aged people.Strengthening health education can reduce the incidence of upper gastrointestinal hemorrhage.