Abstract: Objective: To explore the clinical value of xiaozhiling under ultrasonography guidance in treatment of splenic cyst.Methods: Under ultrasonography guidance， the fluid of splenic cyst was pumped，and 1 /2 cyst-liquid of xiaozhiling was injected into cyst and took out 5 min later， then 1 /8 cyst-liquid xiaozhiling was injected again.Three months later， the cysts were measured again.If there were no significant changes in the splenic cyst， the treatment would be repeated once.Results: Ten of 12 cases recovered， the length of splenic cyst of 2 cases narrowed 2 cm or so and no cases had adverse reaction and reocurred in following up 6 months.Conclusions: The treatment of splenic cyst with injection of xiaozhiling under ultrasonography guidance is simple， few pains for patients， low cost，high safety and cure rate，wide indication and can keep splenic function， so as to be first chosen to treat splenic cyst.