唐冰霜. 替米沙坦对老年糖尿病合并高血压患者胰岛素敏感性及血管内皮功能的影响[J]. 蚌埠医学院学报, 2013, 37(7): 854-855,858.
    引用本文: 唐冰霜. 替米沙坦对老年糖尿病合并高血压患者胰岛素敏感性及血管内皮功能的影响[J]. 蚌埠医学院学报, 2013, 37(7): 854-855,858.
    TANG Bing-shuang. The effect of telmisartan on insulin sensitivity and vascular endothelial function in elderly diabetic patients with hypertension[J]. Journal of Bengbu Medical College, 2013, 37(7): 854-855,858.
    Citation: TANG Bing-shuang. The effect of telmisartan on insulin sensitivity and vascular endothelial function in elderly diabetic patients with hypertension[J]. Journal of Bengbu Medical College, 2013, 37(7): 854-855,858.

    替米沙坦对老年糖尿病合并高血压患者胰岛素敏感性及血管内皮功能的影响

    The effect of telmisartan on insulin sensitivity and vascular endothelial function in elderly diabetic patients with hypertension

    • 摘要: 目的:探讨替米沙坦对老年糖尿病合并高血压患者的胰岛素敏感性及血管内皮功能的影响。方法:老年糖尿病合并高血压的患者68例,随机分为2组,观察组34例服用替米沙坦40 mg每天1次进行治疗;对照组34例服用氨氯地平2.5 mg每天1次,观察2组患者胰岛素敏感性包括空腹血糖(FBG)、空腹胰岛素(FINS)及胰岛素抵抗指数(IRI)和血管内皮功能血浆内皮素-1(ET-1)及一氧化氮(NO)的关系。结果:观察组治疗后FBG、FINS、IRI均较对照组明显下降(P0.01);观察组治疗后ET-1、NO与对照组差异均有统计学意义(P0.01和P0.05)。结论:替米沙坦可有效改善老年糖尿病合并高血压患者的胰岛素敏感性和血管内皮功能。

       

      Abstract: Objective: To study the clinical significance of telmisartan treatment on insulin sensitivity and endothelial function in elderly diabetic patients with hypertension.Methods:Sixty-eight elderly diabetic patients with hypertension were randomly selected in our hospital,and divided into two groups,the patents in study group (34 cases) were required regular quantitative taking alternate telmisartan 40 mg per day treatment; the patients in control group(34 cases) taking amlodipine 2.5 mg per day,the insulin sensitivity including fasting blood glucose(FBG) level,fasting insulin(FINS),insulin resistance index(IRI) and vascular endothelial function including the changes of endothelin-1(ET-1) and nitric oxide(NO) were observed.Results:Compared with the control group,FBG,FINS,IRI in the study group were decreased after telmisartan treatment (P0.01) ; compared with the control group,there had statistical differences of ET-1 and NO in the study group after telmisartan treatment(P0.01 and P0.05).Conclusions:Telmisartan can effectively improve insulin sensitivity and endothelial function in elderly diabetic patients with hypertension.

       

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