The effect of telmisartan on insulin sensitivity and vascular endothelial function in elderly diabetic patients with hypertension
-
摘要: 目的：探讨替米沙坦对老年糖尿病合并高血压患者的胰岛素敏感性及血管内皮功能的影响。方法：老年糖尿病合并高血压的患者68例，随机分为2组，观察组34例服用替米沙坦40 mg每天1次进行治疗;对照组34例服用氨氯地平2.5 mg每天1次，观察2组患者胰岛素敏感性[包括空腹血糖(FBG)、空腹胰岛素(FINS)及胰岛素抵抗指数(IRI)]和血管内皮功能[血浆内皮素-1(ET-1)及一氧化氮(NO)]的关系。结果：观察组治疗后FBG、FINS、IRI均较对照组明显下降(P0.01);观察组治疗后ET-1、NO与对照组差异均有统计学意义(P0.01和P0.05)。结论：替米沙坦可有效改善老年糖尿病合并高血压患者的胰岛素敏感性和血管内皮功能。Abstract: Objective: To study the clinical significance of telmisartan treatment on insulin sensitivity and endothelial function in elderly diabetic patients with hypertension.Methods:Sixty-eight elderly diabetic patients with hypertension were randomly selected in our hospital,and divided into two groups,the patents in study group (34 cases) were required regular quantitative taking alternate telmisartan 40 mg per day treatment; the patients in control group(34 cases) taking amlodipine 2.5 mg per day,the insulin sensitivity including fasting blood glucose(FBG) level,fasting insulin(FINS),insulin resistance index(IRI) and vascular endothelial function including the changes of endothelin-1(ET-1) and nitric oxide(NO) were observed.Results:Compared with the control group,FBG,FINS,IRI in the study group were decreased after telmisartan treatment (P0.01) ; compared with the control group,there had statistical differences of ET-1 and NO in the study group after telmisartan treatment(P0.01 and P0.05).Conclusions:Telmisartan can effectively improve insulin sensitivity and endothelial function in elderly diabetic patients with hypertension.
-
Keywords:
- diabetes /
- hypertension /
- telmisartan /
- insulin sensitivity /
- vascular endothelial function
-
-
[1] 程训民,江时森,马瑞,等.高血压合并糖尿病对心肌微血管内皮细胞功能的影响[J].上海医学,2007,30(Suppl 1):162-163. [1] [2] 宋吉法.硝苯地平缓释片治疗高血压合并糖尿病的临床效果观察[J].中国医药导刊,2012,14(8):1384-1385. [2] [3] 刘士君.硝苯地平缓释片治疗高血压合并糖尿病疗效观察[J].中国美容医学,2011,20(Suppl 2):444-445. [3] [4] 柏瑾,诸骏仁,蔡迺绳,等.替米沙坦治疗轻中度高血压的临床疗效和安全性多中心随机对照临床试验[J].中华心血管病杂志,2002,30(12):738-742. [4] [5] 熊玉卿,李新华,黄鹏,等.替米沙坦在中国健康志愿者体内 的药代动力学特征[J].中国药理学通报,2004,20 (9):1038-1041. [5] [6] 李华波.替米沙坦联合氨氯地平治疗老年轻中度高血压患者60 例[J].中国老年学杂志,2012,32(21):4784-4785. [6] [7] 余伟发,周智明,朱海波,等.替米沙坦及其类似物的合成和生物活性研究[J].有机化学,2006,26(3):318-323. [7] [8] 张瑾,陈绍行.血管紧张肽Ⅱ受体拮抗剂的药动学与临床用药[J].中国新药与临床杂志,2004,23(2):111-115. [8] [9] 王立军,马虹,廖新学,等.替米沙坦对人血管内皮细胞血管紧张素转换酶-2 表达的调节作用研究[J].中国危重病急救医学,2006,18(4):224-228. [9] [10] 陶红,米树华,赵怡,等.替米沙坦对老年高血压伴代谢综合征患者糖代谢的改善作用[J].中国全科医学,2010,13(11):1170-1173.
计量
- 文章访问数: 3082
- HTML全文浏览量: 320
- PDF下载量: 125
下载:
