Abstract: Objective: To explore the relationship between the exact mortality,common risk factors and medication data of the patients infected byKlebsiella pneumoniaecarbapenemase(KPC) production strains in this region.Methods:With the help of electric medical record and the chart,the clinical data of 82 cases infected by KPC-producing strains in department of microbiology in our hospital were analyzed retrospectively.Results:Among these 82 patients,66 cases were infected by KPC / ESBL co-producing isolates,16 cases were infected by KPC producing isolates only.The mortality was 30 cases(45.5%) and 5 cases(31.3%) respectively,and there was no statistical significance(P0.05).In Cox regression analysis,treatment with sulfuric acid polymyxin B had obvious effect(P0.01). Conclusions:The treatment with sulfuric acid polymyxin B had certain herapeutic effect on patients infected by KPC-producing strains.