Abstract: Objective: To investigate the effects of risk assessment and predictive nursing on therapeutic endoscopic retrograde cholangiopancreatography(ERCP) in aged patient.Methods:Routine nursing in 70 aged patients treated with ERCP were implemented from Jan.2010 to Jul.2011 (control group).Risk assessment and predictive nursing in 74 aged patients treated with ERCP were implemented from Aug.2011 to Dec.2012 (experimental group).The ERCP tolerance,success rate of operation and incidence of complications in two groups were compared.Results:There were statistical significances in ERCP tolerance,and the incidence of cholangitis,acute pancreatitis and gastrointestinal hemorrhage between the experimental group and control group(P0.05).There were no statistical significances in the success rate of operation and incidence of perforation in two groups(P0.05).Conclusions:Risk assessment and predictive nursing of therapeutic ERCP in aged patients can effectively improve patient tolerability and significantly reduce the occurrence of postoperative complications.