Abstract: Objective: To study the value of bedside high-frequence ultrasound in diagnosis of neonatal cerebral disease.Methods: Seventy eight cases of neonatal cerebral disease were examined bedside by ultrasound high frequency probe,and the result was compared with that by computer tomography(CT).Results: Intracranial hemorrhage was observed in 33 cases,hypoxic-ischemic encephalopathy in 41 cases,encephalodysplasia in 1 case and intracranial calcification in 3 cases by cerebral ultrasound;The result by ultrasonic examination for cerebral disease coincided with that by computer tomography except subarachnoid hemorrhage,and the changes of the cerebral disease could be monitored by ultrasound.Conclusions: Ultrasound is of high value in diagnosis of neonatal cerebral disease and has the advantages of no radiation injury,convenience,easy application and cost efficacy.