Abstract: Objective: To explore the clinical efficacy and safety of hysteroscopic electrotomy in the treatment of submucosal myoma of uterus. Methods: Forty-six patients with submucosal myoma of uterus were divided into hysteroscopic operation group( 26 cases) and laparotomy group ( 20 cases ) . The time of operation，anal exhaust，ambulation and hospital stay，intraoperative blood loss and postoperative fever rate of two groups were analysed. Results: The operative time and intraoperative blood loss of hysteroscopic operation group were shorter or less than those in laparotomy group ( P ＜ 0. 01 ) . The time of anal exhaust，ambulation and hospital stay of hysteroscopic operation group were significantly shorter than those in laparotomy group( P ＜ 0. 01) . The postoperative fever cases in hysteroscopic operation group and that in laparotomy group the difference was not statistical significance( P ＞ 0. 05) . Conclusions:Hysteroscopic electrotomy in the treatment of submucosal myoma of uterus is good clinical efficacy and safety，which can be the first choice of treatment means.