Abstract: Objective: To evaluate the clinical efficacy and safety of Prolift anterior pelvic floor reconstruction combined with vaginal posterior Gynemesh in the treatment of stage Ⅱto Ⅲ pelvic organ prolapse( POP) . Methods: Twenty-five patients with stage Ⅱto Ⅲ pelvic organ prolapse rated by POP quantification( POP-Q) were treated with Prolift anterior pelvic floor reconstruction combined with vaginal posterior Gynemesh. The changes of the indicators and complications of all patients were analysed by subjective assessment ( according to pelvic organ prolapse quality of life score) and Objective assessment ( according to POP-Q examination score) in perioperative and postoperative period. Results: The operation time and blood loss amount were ranging from 30 to 60minutes and ranging from 30 to 90 ml， respectively. No surrounding organ damage and massive hemorrhage were found. The mean hospital stays time and median following up time were ranging from 3 to 6 days and ranging from 1 to 12 months， respectively. No vaginal wall and uterine prolapse were found at 4 weeks after the operation. The postoperation indicators of POP-Q and the score of pelvic floor function were lower than those in preoperation( P ＜0. 01) . Conclusions: Prolift anterior pelvic floor reconstruction combined with vaginal posterior Gynemesh is few complications， light pain， qucik recovery， economy and safe. Its short-term curative effects are good， and long-term effects are uncertain.