余清. 丙泊酚与七氟烷麻醉对骨科老年手术患者术后认知功能的影响[J]. 蚌埠医学院学报, 2013, 37(8): 982-984.
    引用本文: 余清. 丙泊酚与七氟烷麻醉对骨科老年手术患者术后认知功能的影响[J]. 蚌埠医学院学报, 2013, 37(8): 982-984.
    YU Qing. Effect of propofol and sevoflurane anesthesia on postoperatively cognitive function of aged patients in orthopedics[J]. Journal of Bengbu Medical College, 2013, 37(8): 982-984.
    Citation: YU Qing. Effect of propofol and sevoflurane anesthesia on postoperatively cognitive function of aged patients in orthopedics[J]. Journal of Bengbu Medical College, 2013, 37(8): 982-984.

    丙泊酚与七氟烷麻醉对骨科老年手术患者术后认知功能的影响

    Effect of propofol and sevoflurane anesthesia on postoperatively cognitive function of aged patients in orthopedics

    • 摘要: 目的:探讨丙泊酚与七氟烷对骨科老年手术患者术后认知功能的影响。方法:将行骨科手术的120例老年患者随机分为丙泊酚组和七氟烷组各60例。麻醉诱导后,丙泊酚组患者予以丙泊酚靶控输注泵泵注丙泊酚1~3g/ml维持麻醉,七氟烷组予以1%~3%七氟烷吸入维持麻醉。对2组患者手术前后的血清S100水平和认知功能进行比较。结果:丙泊酚组患者术后1、3和6 h认知功能得分均较术前下降(P0. 01),术后1 d认知功能得分与术前相比,差异无统计学意义(0. 05);而术后3 d认知功能得分则高于术前(P0. 01)。七氟烷组患者术后1、3、6 h认知功能得分均较术前下降(P0. 01),术后1、3 d认知功能得分与术前相比,差异均无统计学意义(0. 05)。七氟烷组患者术后1 h、3 h、6 h、1 d和3 d认知功能得分均低于丙泊酚组(P0. 01)。术后2组患者血清S100水平均较术前显著升高(P0. 01),而且七氟烷组患者显著高于丙泊酚组(P0. 01)。结论:丙泊酚与七氟烷均可影响患者的认知功能,其中七氟烷对认知的影响最为严重。

       

      Abstract: Objective: To explore the effects of propofol and sevoflurane anesthesia on postoperatively cognitive function of aged patients in orthopedics. Methods: One hundred and twenty aged patients undergone orthopedic surgery were randomly divided into propofol and sevoflurane group( 60 cases, each group) . The propofol and sevoflurane group were anesthetized by injection 1 to 3 g /ml of propofol and inhalation 1% to 3% of sevoflurane after anesthesia induction,respectively. The serum levels of S100 and cognitive function in two groups were compared before and after operation. Results: Compared with preoperation, the scores of cognitive function in the propofol group decreased at 1,3 and 6 hours after operation( P < 0. 01) , the difference of cognitive function score beteween postoperative 1 hour and before operation has no statistic significance( P > 0. 05) ,but its score at postoperative 6 days was higher( P < 0. 01) . Compared with preoperation, the scores of cognitive function in the sevoflurane group decreased at 1,3,6, 24 and 72 hours after operation( P < 0. 01) , the differences of cognitive function score beteween postoperative 1 and 72 hours and before operation have no statistic significance( P > 0. 05) . The scores of cognitive function in the sevoflurane group were lower than those in propofol group at 1,3,6, 24 and 72 hours after operation( P<0. 01) . Compared with preopration, the postoperative serum levels of S100 protein in two groups were significant higher( P <0. 01), the level of S100 in the sevoflurane group was significantly higher than those in propofol group( P <0. 01) . Conclusions: Both propofol and sevoflurane affect the patient's cognitive function, the effect of sevoflurane is the most.

       

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