Abstract: Objective: To observe the hemodynamic change of hepatic artery and portal vein in patients with hepatolenticular degeneration( HLD) complicated with hypersplenism before and after splenectomy. Methods: The hemodynamics of hepatic artery and portal vein in 46 patients with HLD complicated by hypersplenism were detected by color doppler ultrasound at preoperation and 7 and 14 days after splenectomy， all data were analyzed. Results: Compared with preoperation， the reducing diameter of main and right branch of portal vein and slowing of blood flow velocity were statistical significance at 7 days after splenectomy( P ＜ 0. 05 － P ＜ 0. 01) . The blood flow velocity of the right branch of portal vein at 14 days after splenectomy was higher than that in postoperative 7 days( P ＜0. 01) . There were not statistically significant in the diameter of main and right branch of portal vein and the peak velocity and resistance index of right hepatic artery between preoperation and postoperative 7 days and 14 days ( P ＞ 0. 05) . Conclusions: The hemodynamic change of hepatic artery and portal vein in patients with HLD complicated with hypersplenism after splenectomy is significant.