Abstract: Objective: To investigate the disease uncertainty and quality of life of patients with type 2 diabetes,and explore the effects of disease uncertainty on their quality of life.Methods: Sixty patients with type 2 diabetes were investigated using Mishel's uncertainty in illness and diabetes specific quality of life scale,and the result of which was analyzed.Results: The total scores of disease uncertainty in all cases were(88.64±12.65),which was medium level.The scores of quality of life in all cases were(62.12±10.53).The levels of disease uncertainty in patients were negatively correlated to the total scores of their quality of life and the score of their social dimension(P<0.05).Conclusions: Clinical medical staff and community workers should strengthen the diabetic knowledge education,which can decrease the level of disease uncertainty in patients with type 2 diabetes and improve their quality of life.