不稳定型心绞痛伴抑郁症的抗抑郁药疗效

Effect of anti-depression drug on patients with unstable angina pectoris combined with depression

摘要: 目的:观察抗抑郁药对不稳定型心绞痛伴抑郁症的疗效。方法:58例随机分成干预组28例,常规组30例,在常规治疗基础上干预组每日口服帕罗西汀20~60mg或西酞普兰10~40mg,均观察8周。结果:干预组能有效改善抑郁症状,并可提高心绞痛缓解率(P<0.05),但对心绞痛患者的缺血心电图无改善作用(P>0.05)。结论:抗抑郁药可改善不稳定型心绞痛伴抑郁症患者的抑郁症状和心绞痛症状,提高患者的生活质量。

Abstract: Objective: To observe the curative effect of anti-depression drug in treatment of patients with unstable angina pectoris accompanied by depression.Methods: Fifty-eight patients were randomly divided into two groups.In addition to the routine therapy,the treatment group were administered paroxetine 20-60 mg a day or xitaipulan 10-40 mg a day orally.Both groups were observed for eight weeks.Results: The symptom of depression in the treatment group was improved and the angina pectoris released(P<0.05),but no obvious effect was observed in the electrocardiogram of patients with unstable angina pectoris(P>0.05).Conclusions: Anti-depression drug may effectively relieve the symptom of depression and the angina pectoris,and improve the life quality of patients with unstable angina pectoris.