Abstract: Objective: To investgate the expression and clinical significance of the deathreceptor 5(DR 5) and decoyreceptor 2(DcR 2) of TNF-related apoptosis-inducing ligand (TRAIL) in endometrial cancer. Methods: The expressions of DR5 and DcR2 of endometrium tissues from 52 cases with endometrial cancer,20 cases with atypical endometrium hyperplasia and 23 cases normal endometrium tissue were detected by immunohistochemistry. The pathological grade of surgery, tumor differentiation degree, tissue type, muscular layer infiltration and clinical pathological factors of endometrial cancer were analyzed. Results: The expressions of DcR2 of normal endometrium tissue were higher than that of endometrial cancer tissue (P ＜ 0. 01 ) . The expressions of DR5 of normal endometrium,atypical endometrium hyperplasia and endometrial cancer tissue showed increasing trend,the Results of multiple comparison had statistically significant (P ＜ 0. 01) . Conclusions: Endometrium carcinoma cells can be easily induced apoptosis by TRAIL with high expression of DR5 and low expression of DcR2,which can provide a basis for treating endometrium carcinoma.