刘媛媛, 潘莉, 郭晋, 吴晓飞. 急性脑梗死患者血清VEGF及Ang-1水平的动态变化及其意义[J]. 蚌埠医学院学报, 2012, 36(10): 1178-1180.
    引用本文: 刘媛媛, 潘莉, 郭晋, 吴晓飞. 急性脑梗死患者血清VEGF及Ang-1水平的动态变化及其意义[J]. 蚌埠医学院学报, 2012, 36(10): 1178-1180.
    LIU Yuan-yuan, PAN Li, GUO Jin, WU Xiao-fei. The dynamic changes of VEGF and Ang-1 levels in serum and its significance of patients with acute cerebral infarction[J]. Journal of Bengbu Medical College, 2012, 36(10): 1178-1180.
    Citation: LIU Yuan-yuan, PAN Li, GUO Jin, WU Xiao-fei. The dynamic changes of VEGF and Ang-1 levels in serum and its significance of patients with acute cerebral infarction[J]. Journal of Bengbu Medical College, 2012, 36(10): 1178-1180.

    急性脑梗死患者血清VEGF及Ang-1水平的动态变化及其意义

    The dynamic changes of VEGF and Ang-1 levels in serum and its significance of patients with acute cerebral infarction

    • 摘要: 目的:研究血管内皮生长因子(VEGF)及血管生成素-1(Ang-1)水平在急性脑梗死患者血清中的动态变化,并探讨2种生长因子水平与梗死面积的关系以及二者之间的关系。方法:采用ELISA法分别测定对照组35名及急性脑梗死患者50例起病48 h内、3 d、7 d、14 d、21 d血清中VEGF及Ang-1水平。结果:脑梗死患者血清VEGF水平在病程各时间点均高于对照组(P0.01),且呈动态变化,于起病3 d达高峰(P0.01),VEGF水平与梗死面积具有一定关系(P0.05~P0.01)。脑梗死患者血清Ang-1水平在起病7 d升高,14 d达高峰;血清Ang-1水平与梗死面积也有一定关系,且与VEGF水平呈正相关关系(P0.05)。结论:急性脑梗死患者血清中VEGF及Ang-1水平明显增高,提示这2种血管生长因子参与了缺血性脑损伤的病理生理过程,且其水平测定对判断梗死灶大小具有一定意义。

       

      Abstract: Objective: To investigate the dynamic changes of vascular endothelial growth factor(VEGF) and angiopoietin-1(Ang-1) levels in serum and its significance of patients with acute cerebral infarction and the relationship between the content of two kinds of growth factor and infarction area, and theirselves. Methods: The serum levels of VEGF and Ang-1 of 30 controls and 50 patients with acute cerebral infarction at hours 48,days 2,3 ,7 , 14 and 21 were measured by ELISA. Results: The levels of VEGF in patients with acute cerebral infarction at different time-points were significantly higher than that of control group(P < 0. 01) ,which were dynamic changes and peaked on the 3rd day(P < 0. 01) . The levels of VEGF were closely related to infarction size(P < 0. 05 ~ P < 0. 01) . The levels of Ang-1 in patients with acute cerebral infarction increased on the 7th day and peaked on the 14th day,which were related to infarction size and positive correlation with VEGF content(P < 0. 05) . Conclusions: The serum levels of VEGF and Ang-1 in patients with cerebral infarction increase significantly,which suggest that the two angiogenic factros involve in the pathophysiological process of ischemic brain damage. The serum levels of VFGF and Ang-1 have a certain significance to estimate the infarction size.

       

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