Abstract: ObjectiveTo explore the feasibility of thoracoscopy and laparoscopy combined with Mckeown in esophageal cancer operation. Methods: Eight cases with esophageal cancer( including superior segment in 1 case，middle segment in 5 cases and inferior segment in 2 cases) were treated with thoracoscopy and laparoscopy combined with Mckeown.Mediastinal lymph nodes of all cases were dissected in thoracic segment of the esophagus using thoracoscopy in prone position of left half.Gastroesophageal anastomosis in left neck of all cases were implemented using laparoscopy in supine postion Results: All operations were successful，no conversion to open surgery and death during perioperative period were found.The operation time，blood loss，number of dissected lymph nodes and postoperative hospital stay were 240 to 400 minutes， 120 to 420 ml，4 to 22 and 14 to 19 days， respectively.One case with respiratory failure was found，who cured after the breathing machine auxiliary treatment.One case with hoarseness was found.All patients were followed up for 2 to 11 months and survival. Conclusions: The thoracoscopy and laparoscopy combined with Mckeown for treating esophageal cancer is safe and feasible，which is worthy of being widely applied in clinic.