Abstract: ObjectiveTo investigate the clinical curative effects， safety and immune function influence of oxaliplatin combined with capecitabine in the treatment of patients with gastric cancer. Methods: Fifty-two patients with gastric cancer were randomly divided into treatment group and control group( 26 cases each group) .The control group were treated with oxaliplatin combined with 5-fluorouracil and calcium folinate.the treatment group were treated with oxaliplatin combined with capecitabine.The curative effects， levels of T cell subgroup and incidence of adverse reactions of two groups were compared.Results: The total effective rates of the control group and treatment group were 61.54% and 65.38%， the difference of which had no statistical significance( P 0.05) .Compared with before chemotherapy， the levels of CD3 + and CD4 + of two groups decreased after chemotherapy and 2 days in chemotherapy( P 0.05 to P 0.01) .The differences of the levels of CD3 + after chemotherapy and CD4 + after chemotherapy and 2 days in chemotherapy in two groups had statistical significance( P 0.05 to P 0.01) .The levels of CD8 + in two groups did not obviously change before and after chemotherapy， the difference of which had no statistical significance ( P 0.05) .The incidence of nausea and vomiting，hand-foot syndrome and granulocyte declining in treatment group were lower than those in control group( P 0.05 to P 0.01) . Conclusions:Oxaliplatin combined with capecitabine in the treatment of patients with gastric cancer is good effects，high safety and little influence on immunity，which can protect the T cell subgroup， conducive to the rehabilitation of patients，be worthy of being widely applied in clinic.