Abstract: ObjectiveTo explore the effects of different dosage atorvastation on the levels of inflammatory factors in patients with acute coronary syndrome( ACS) after percutaneous coronary intervention( PCI) . Methods: One hundred and ten patients with ACS after PCI were divided into experimental group and control group( 55 cases each group) .Inaddition to conventional therapy， the control group were treated with 10 mg /d of atorvastation by oral， the experimental group were treated with 40 mg /d of atorvastation by oral form before operation.The serum levels of C-reactive protein( CrP) ， troponin I( cTnI) ， fiber Fib( FIB) and D-dimer( DD) in two groups were measured on the day of operation and postoperative two weeks.Results: The differences of CrP， cTnI，FIB and DD levels in two group had no statistical significance before operation( P 0.05) .Compared with before operation， the levels of CrP，cTnI，FIB and DD in control group were increased after PCI( P 0.05 to P 0.01) ，but the four indexes change in the experimental group were not obvious( P 0.05) .The levels of CrP， cTnI and FIB in control group were higher than those in experimental group after operation( P 0.01) . Conclusions: PCI can elevate the levels of CrP， cTnI，FIB and DD.Atorvastation can help to control the inflammatory factors levels，reduce inflammatory reaction after PCI.