The effect of different dosage atorvastation on the levels of inflammatory factors in patients with acute coronary syndrome after PCI
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摘要: 目的:观察不同剂量阿托伐他汀对急性冠状动脉综合征(ACS)行经皮冠状动脉介入术(PCI)后患者炎症因子的影响。方法:110例行PCI的ACS患者随机分为2组,除常规治疗外,对照组55例给予阿托伐他汀10 mg/d口服,观察组55例于术前1 d开始增加至40 mg/d口服。分别于术前及术后2周采空腹静脉血,测定血浆C反应蛋白(CRP)、肌钙蛋白I(cTnI)、纤维蛋白原(FIB)、D-二聚体(DD)。结果:2组术前CRP、cTnI、FIB、DD差异均无统计学意义(P0.05),对照组术后CRP、cTnI、FIB、DD均较术前升高(P0.05~P0.01),而观察组术后4项指标变化不明显(P0.05)。对照组术后CRP、cTnI、FIB均明显高于治疗组(P0.01)。结论:PCI后可导致血清CRP、cTnI、FIB、DD水平升高,强化阿托伐他汀治疗有助于控制血浆炎症因子,减少PCI术后炎症反应。Abstract: ObjectiveTo explore the effects of different dosage atorvastation on the levels of inflammatory factors in patients with acute coronary syndrome( ACS) after percutaneous coronary intervention( PCI) . Methods: One hundred and ten patients with ACS after PCI were divided into experimental group and control group( 55 cases each group) .Inaddition to conventional therapy， the control group were treated with 10 mg /d of atorvastation by oral， the experimental group were treated with 40 mg /d of atorvastation by oral form before operation.The serum levels of C-reactive protein( CrP) ， troponin I( cTnI) ， fiber Fib( FIB) and D-dimer( DD) in two groups were measured on the day of operation and postoperative two weeks.Results: The differences of CrP， cTnI，FIB and DD levels in two group had no statistical significance before operation( P 0.05) .Compared with before operation， the levels of CrP，cTnI，FIB and DD in control group were increased after PCI( P 0.05 to P 0.01) ，but the four indexes change in the experimental group were not obvious( P 0.05) .The levels of CrP， cTnI and FIB in control group were higher than those in experimental group after operation( P 0.01) . Conclusions: PCI can elevate the levels of CrP， cTnI，FIB and DD.Atorvastation can help to control the inflammatory factors levels，reduce inflammatory reaction after PCI.
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