Abstract: ObjectiveTo investigate the effects of posterior monosegmental fixation combined with single cage bone graft in thetreatment of lumbar spondylolisthesis. Methods: Forty-eight cases with lumbar spondylolisthesis were treated with posterior monosegmental fixation combined with single cage bone graft， the bone graft fusion time and postoperative excellent rate of all cases were observed.Results: Forty-six cases were followed up for 11 to 30 months.The bone graft fusion time was 4 to 9 months.Solid fusion in 43 cases，probable fusion in 2 cases and no fusion in 1 case were found， the infusion rate was 97.83%.The postoperative effects of 25cases， 19 cases and 2 cases were excellent， good and ordinary， respectively， the excellent and good rate was 95.65%. Conclusions: The posterior monosegmental fixation combined with single cage bone graft in the treatment of lumbar spondylolisthesis is good reset and fixation， and high fusion rate.