Abstract: Objective: To investigate the effects of psychological intervention on sexual function and quality of patients treated with vaginoplasty. Methods: Forty-two cases with vaginoplasty were divided into the control group(20 cases) ,which was treated with the conventional perioperative care and discharge guidance, and the intervention group(22 cases) ,which was treated with added 12 months of comprehensive psychological behavior intervention. At 3,6 and 12 months post-operation, the effects of nuring of all cases were investigated according to sexual Quality of Life Questionnaire for Women(SQLQ-W) and Quality of Live Brief Questionnaire(QOLBREF) . Results: The scores of the SQLQ-W and QOL-BREF of two groups were obviously enhanced at 6 and 12 months post-operation, and significant differences were found(P ＜ 0. 05-P ＜ 0. 01) . The score difference of the SQLQ-W of two groups had no statistical significance at 3 and 6 months post-operation (P ＞ 0. 05) ,while at 12 months post-operation the scores of intervention group were significant higher that of the control group. At 6 and 12 months post-operation, the scores of QOL-BREF of intervention group were higher that of the control group(P ＜ 0. 01) . Conclusions: The psychological intervention can improve the sexual function and quality of patients treated with vaginoplasty.