Abstract: Objective: To explore the efficacy of systemic chemotherapy combined with percutaneous ethanol injection(PEI) treatment on breast carcinoma postoperative patients with liver metastasis. Methods: Fifteen cases were all breast cancer postoperative patients with liver metastasis. All patients were received paclitaxel toisplatin(TP) protocol. The treatment included systemic chemotherapy of paclitaxel 135 mg /m2 intravenous injection on first day followed by cisplatin 30 mg /d for 3 days, 28 days for one cycle, and each patient was experienced for more than 4 courses. Metastatic tumor foci of liver was also received therapy of PEI under ultrasound-guided. Each foci was experienced treatment for 2 to 4 times. results: Three cases were complete remission, 12 cases were partial remission, the total response rate was 100%. All patients survived for more than 6 months, in 10 cases of death, one patient survived for 22 months. Adverse reaction included lower appetite，nausea，vomiting，neutropenia, transient liver function abnormalities and the puncture site pain. Conclusions: The combination of PET and systemic chemotherapy by TP protocol may be an effective treatment to postoperative patients with breast carcinoma and hepatic metastasis.