Clinical observation of systemic chemotherapy combined with percutaneous ethanol injection treatment on breast carcinoma postoperation with liver metastasis
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摘要: 目的:观察静脉化疗联合经皮穿刺无水乙醇瘤内注射(PEI)治疗乳腺癌伴肝转移的疗效。方法:15例均为乳腺癌术后并确诊有肝转移,给予化疗(TP方案):紫杉醇135 mg/m2,第1天,静脉输注;顺铂40 mg/d,第2~4天,静脉输注。28 d为1周期,均用4疗程以上。同时化疗前、后肝转移瘤灶给予彩超引导下PEI治疗,每个病灶最少2次,最多4次。结果:完全缓解3例,部分缓解12例,有效率100%;均存活6个月以上,10例病死患者中最长存活22个月。不良反应为食欲低下、恶心呕吐、白细胞减少、肝功能一过性异常和穿刺部位疼痛。结论:PET和TP方案静脉全身化疗对乳腺癌术后肝转移有一定疗效。Abstract: Objective: To explore the efficacy of systemic chemotherapy combined with percutaneous ethanol injection(PEI) treatment on breast carcinoma postoperative patients with liver metastasis. Methods: Fifteen cases were all breast cancer postoperative patients with liver metastasis. All patients were received paclitaxel toisplatin(TP) protocol. The treatment included systemic chemotherapy of paclitaxel 135 mg /m2 intravenous injection on first day followed by cisplatin 30 mg /d for 3 days, 28 days for one cycle, and each patient was experienced for more than 4 courses. Metastatic tumor foci of liver was also received therapy of PEI under ultrasound-guided. Each foci was experienced treatment for 2 to 4 times. results: Three cases were complete remission, 12 cases were partial remission, the total response rate was 100%. All patients survived for more than 6 months, in 10 cases of death, one patient survived for 22 months. Adverse reaction included lower appetite，nausea，vomiting，neutropenia, transient liver function abnormalities and the puncture site pain. Conclusions: The combination of PET and systemic chemotherapy by TP protocol may be an effective treatment to postoperative patients with breast carcinoma and hepatic metastasis.
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Keywords:
- breast neoplasms /
- liver metastasis /
- ethanol /
- percutaneous injection
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[1] 刘宏，兰守丽，赵馥，等. 无水酒精注射治疗晚期肝转移癌 [J]. 河南肿瘤学杂志，2 004，1 7(6): 426-427. [1] [2] 尹预真，周菊英. 乳腺癌术后肝转移34 例相关性因素分析 [J]. 南通大学学报: 医学版，2 009，2 9(1): 44-45. [2] [3] 朱文晖，肖际东，李瑞珍，等. 彩超引导下酒精注射治疗小肝 癌的疗效观察[J]. 实用预防医学，2 005，1 2(4): 921-923. [3] [4] 郭佳，杨甲梅，吴孟超，等. 超声介入无水酒精瘤内注射治疗 肝癌的意义: 附2 000 例报告[J]. 中国实用外科杂志，2001, 21(8): 494-495. [4] [5] Curley SA. 肝脏肿瘤[M]. 北京: 人民卫生出版社，2 001: 181. [5] [6] Matsumoto J，Minami T，Takami M，et al. A case respectable hepatic metasases of breast cancer following intrahepaticarterial chemotherapy[J]. Gan To Kagaku ryoho，1996，23 (11 ): 1542-1545.
[6] [7] 李继军，刘作勤，唐军，等. 肺癌肝转移的血供特点及介入栓 塞治疗分析[J]. 医学影像学杂志，2 008，1 8(7): 759-761. [7] [8] 王洪武. 现代肿瘤靶向治疗技术[M]. 北京: 中国医药科技出 版社，2 005: 413-416. [8] [9] Sung YM，Choi D，Lim HK，et al. Long-term results of percutaneous ethanol injection for the treatment of hepatocellular carcinoma in Korea[J]. Korean J radiol，2006，7 (3 ): 187-192.
[9] [10] Lin LW，Lin XY，He YM，et al. Experimental and clinical assessment of percutaneous hepatic quantified ethanol injection in treatment of hepatic carcinoma[J]. World J Gastroenterol，2004, 10(21): 3112-3117.
[10] [11] 姚春梅，尹刘. 紫杉醇为主的联合方案治疗蒽环类耐药的晚 期乳腺癌46 例[J]. 安徽医学，2 009，3 0(4): 418-419. [11] [12] 朱燕，赵玉亮，方虹，等. 紫杉醇联合顺铂治疗31 例晚期乳腺 癌的临床观察[J]. 中国肿瘤临床，2 008，3 5(7): 369-371.
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