Abstract: Objective: To explore the clinical effect of Nano-silver dressing in treatment of pediatric deep partial-thickness burn. Methods: A total of 80 patients with deep partial thickness burn were randomly divided into two groups，with 40 in each one. The control group was applied with silver zinc cream and the observation group was applied with nano-silver dressing. The dressing was changed every other day. The patients' bacteria infection, symptoms, the occurrence of high fever at 7th day and the healing time, recovering rate at 2nd，6th, 10th, 14th, 18th day were compared between the two groups. results: In the observation group, the bacteria infections and the occurrence of high fever at 7th day were significantly lower than the control(P ＜ 0. 05 and P ＜ 0. 01) ，and the healing time and recovering rate at 6th，10th and 14th day were superior to the control group(P ＜ 0. 01) . Conclusions: Nano silver dressing is quite effective in counteracting infection and promoting the wound healing.