朱俊锋, 周黎黎, 耿英华, 张凤, 杨艳丽, 夏瑞祥. 淋巴瘤组织中B7-H4的表达及其临床意义[J]. 蚌埠医学院学报, 2013, 37(10): 1288-1290.
    引用本文: 朱俊锋, 周黎黎, 耿英华, 张凤, 杨艳丽, 夏瑞祥. 淋巴瘤组织中B7-H4的表达及其临床意义[J]. 蚌埠医学院学报, 2013, 37(10): 1288-1290.
    ZHU Jun-feng, ZHOU Li-li, GENG Ying-hua, ZHANG Feng, YANG Yan-li, XIA rui-xiang. The expression of B7-H4 in lymphoma and its clinical significance[J]. Journal of Bengbu Medical College, 2013, 37(10): 1288-1290.
    Citation: ZHU Jun-feng, ZHOU Li-li, GENG Ying-hua, ZHANG Feng, YANG Yan-li, XIA rui-xiang. The expression of B7-H4 in lymphoma and its clinical significance[J]. Journal of Bengbu Medical College, 2013, 37(10): 1288-1290.

    淋巴瘤组织中B7-H4的表达及其临床意义

    The expression of B7-H4 in lymphoma and its clinical significance

    • 摘要: 目的:探讨B7-H4在淋巴瘤组织中的表达及其临床意义。方法:应用EliVision plus免疫组织化学法检测B7-H4在30例非霍奇金淋巴瘤(NHL)、7例霍奇金淋巴瘤(HL)及8例良性增生性淋巴结炎组织中的表达,并分析其与性别、年龄及临床分期的相关性。结果:37例淋巴瘤患者B7-H4阳性率为54.1%,良性增生性淋巴结炎患者阳性率为0/8,差异有统计学意义(P0.05)。NHL患者B7-H4阳性率为56.7%,HL阳性率为3/7,差异无统计学意义(P=0.680)。37例淋巴瘤患者中,Ⅰ/Ⅱ期患者B7-H4阳性率为18.8%,Ⅲ/Ⅳ期患者阳性率为81%,差异有统计学意义(P=0.000 2);不同性别和年龄间B7-H4阳性率差异均无统计学意义(P=0.330和P=0.746)。结论:B7-H4与淋巴瘤的发病有关,可作为淋巴瘤与良性增生性淋巴结炎鉴别的有效指标,但对于HL与NHL的鉴别无临床意义。

       

      Abstract: Objective: To investigate the expression of B7-H4 in lymphoma and and its clinical significance. Methods: The expression of B7-H4 in 30 patients with non-Hodgkin lymphoma(NHL) ,7 patients with Hodgkin lymphoma(HL) and 8 patients with benign hyperplastic lymphadenitis were detected using EliVision Plus immunohistochemistry. The correlation of B7-H4 expression with gender, age and disease stage were analyzed by clinical pathology data. results: The positive rate of B7-H4 expression in lymphoma(37 cases) and benign hyperplastic lymphadenitis (8 cases) patients were 54. 1%) and 0. 0%,respectively,the difference of which was statistically significant(P < 0. 05) . The positive rate of B7-H4 expression in NHL and HL patients were 56. 7% and 3 /7, respectively, the difference of which was not statistically significant(P = 0. 680) . The positive rate of B7-H4 expression in stage Ⅰ/Ⅱand Ⅲ/Ⅳ patients were 18. 8% and 81. 0%, respectively, the difference of which was statistically significant(P = 0. 000 2) . The differences of positive rates of B7-H4 expression between gender and age in 37 cases with lymphoma were not statistical significance(P = 0. 330 and P = 0. 746) . Conclusions: The expression of B7-H4 is associated with the pathogenesis of lymphoma,which can be used as an effective index to identify the lymphoma and benign hyperplastic lymphadenitis, and has not clinical value between HL and NHL.

       

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