Abstract: Objective: To observe the outcomes of pernicious placenta previa pregnancy and neonate. Methods: Two hundred and twenty cases with placenta previa were divided into pernicious placenta previa group(38 cases) and normal placenta previa group(182 cases) . The rate of postpartum hemorrhage，placenta implantation，hysterectomy，cesarean section，premature birth，neonatal asphyxia and neonatal mortality of two groups were compared. results: The differences of the rate of postpartum hemorrhage，placental implantation，hysterectomy, cesarean section，preterm birth，neonatal asphyxia and neonatal death between two groups were statistically significant(P ＜ 0. 05 to P ＜ 0. 01) . Conclusions: The harm of pernicious placenta previa to mother and infant is great. Strengthening pregnancy care and the effective preoperation and operation treatment can improve the prognosis of mother and infant in pernicious placenta previa.