儿童过敏性紫癜性肾炎相关危险因素分析

    Analysis of correlated risk factors of nephritis in children Henoch-Schonlein purpura

    • 摘要: 目的:探讨儿童过敏性紫癜性肾炎(HSPN)的相关危险因素。方法:回顾性分析186例过敏性紫癜(HSP)患儿的临床资料,根据尿常规检查结果分为HSPN组56例和非HSPN组130例,采用单因素分析和多因素非条件logistic回归分析HSPN的相关危险因素。结果:单因素分析提示反复皮疹、并发关节症状、消化道出血和腹痛共4个变量因素影响HSPN的发生(P0.05~P0.01);多因素非条件logistic回归分析表明反复皮疹、并发关节症状和腹痛是HSPN的危险因素(P0.01)。结论:反复皮疹、关节症状和腹痛是肾损害不可忽视的危险因素,对出现上述因素的HSP患儿应严密观察随访,并采取积极有效的措施防止肾损害的发生和发展。

       

      Abstract: Objective: To study the correlated risk factors of children Henoch-Schonlein purpura nephritis(HSPN) . Methods: One hundred and eighty-six Henoch-Schonlein purpura (HSP) children were reviewed and analyzed. According to the routine urinary examination, children were divided into HSPN group(n = 56) and non-HSPN group(n = 130) , and then monofactorial analysis and nonconditional logistic analysis were performed to evaluate the risk factors in children with HSPN. results: In univariate analysis, frequent occurrence of purprua, arthrosis symptom,hemorrhage of digestive tract and abdominal pain were identified as factors associated with nephritis(P < 0. 05 to P < 0. 01) . Logistic regression analysis showed that nephritis was significantly associated with frequent occurrence of purprua, arthrosis symptom and abdominal pain(P < 0. 01) . Conclusions: Frequent occurrence of purprua,arthrosis symptom and abdominal pain are high factors towards renal damage that can not be neglected. Patients with these risk factors should be rigorously monitored and need to take positive measures to prevent the development and progression of renal damage.

       

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