Abstract: Objective: To investigate the feasibility and sensitivity of Montreal cognitive assessment(MoCA) and mini-mental state examination(MMSE) in the evaluation of mild cognitive impairment(MCI) in patients with chronic alcoholism(CA) . Methods: The cognitive function of 60 patients with CA(CA group) and 30 healthy people(control group) were evaluated by MoCA and MMSE. results: The differences of the scores of MoCA and MMSE between CA group and control group were statistically significant(P ＜ 0. 01) . The differences of the visual space and memory and reaction abilities in two groups were statistically significant(P ＜ 0. 01) . Conclusions: The federated applications of MoCA and MMSE are beneficial to find the MCI patients with CA in the early stage. The memory and sensitivity of the impairment in local cognitive domain evaluated by MoCA are better than MMSE. MoCA can provide an evidence for early finding，preventing and treating the cognitive impairment in patients with CA.