Abstract: Objective: To investigate the effects of the mosaicplasty with autologous cartilage in the treatment of the cartilaginous lesions of knee joint. Methods: Twenty-three patients were treated with mosaicplasty with autologous cartilage. The clinical effects in all cases were evaluated by Lysholm score, international cartilage repair society and histopathological examination. results: The difference of the excellent rate between before operation and 6 months after operation in all patients had statistical significance (P ＜ 0. 01) . Compare with before operation, the lesion degree was significantly improved(P ＜ 0. 01) . The swelling and pain in 3 cases were found during the following up period，which recovered by articular cavity infusion and lavage. The osteoarthritis，deep infection and deep venous thrombosis were not found. Conclusions: The effects of the mosaicplasty with autologous cartilage in the treatment of the cartilaginous lesions of knee joint are good，which is worthy of being widely applied in clinic.