Abstract: Objective: To investigate the effects of cognitive behavioral nursing therapy on the negative emotions of patients with somatoform disorders. Methods: Sixty-eight patients with somatoform disorder were randomly divided into observation group and control group(34 cases each group) . Two groups were treated with drug therapy and routine nursing, the observation group were additionally treated with cognitive behavior nursing intervention(education intervention) ，psychological intervention and relaxation training, etc. The intervention effects were evaluated by self-evaluation depression scale(SDS) , self-evaluation anxiety scale(SAS) and symptom selfassessment scale(SCL-90) before and after the intervention. results: The differences of SAS，SDS and SCL-90 scores between two groups were not statistically significant before intervention(P ＞ 0. 05) . Twelve weeks after cognitive behavioral nursing therapy, the depression and anxiety levels of the observation group were significantly lower than those in control group and before intervention(P ＜ 0. 01) , the factor scores of somatization，depression and anxiety, interpersonal sensitivity of SCL-90 in observation group were better than those in control group (P ＜ 0. 01) . Conclusions: Cognitive behavioral nursing therapy can significantly improve the depression, anxiety and level of mental health in patients with somatoform disorder, and promote patients recovery.