Abstract: Objective: To observe investigate the efficacy and safety of preemptive analgesia with flurbiprofen axetil in preventing postoperative restlessness of patients under general anaesthesia with remifentanil. Methods: One hundred and twenty patients under general anaesthesia with remifentanil were evenly divided into two groups(group F and group C) . Group F were intravenously injected with flurbiprofen axetil 50 mg and group C were injected with placebo(fat emulsion) 5 ml before surgery. The anesthesia awaking time, extubation time and postoperative restlessness were observed in the two groups, and the postoperative analgesia was evaluated by visual analogue scale. Results: When flurbiprofen axetil was used as preemptive analgesia, the postoperative restlessness rate was 5. 0% in group F, which was obviously lower than the 41. 7% in group C(P ＜ 0. 01) . Conclusions: Preemptive analgesia with flurbiprofen axetil can effectively prevent the postoperative restlessness of patients under general anaesthesia with remifentanil.