Abstract: Objective: To explore the surgical treatment of hilar cholangiocarcinoma and its prognosis factors. Methods: The clinical data of 103 cases with hilar cholangiocarcinoma were analyzed retrospectively. Among 103 cases,28 cases were treated with radical resection,12 cases were treated with palliative resection,34 cases were treated with percutaneous transhepatic cholangial drainage( PTCD) combined with percutaneous biliary stent implantation and 29 cases were treated with PTCD. Results: Their median survival time were( 26. 00 1. 51),( 16. 00 1. 49),( 12. 00 1. 83) and( 5. 00 1. 49) months,respectively,the time differences had statistical significance( P 0. 01). The Bismuth type,lymph node metastasis and intraoperative chemotherapy affected the prognosis of patients with hilar cholangiocarcinoma. Conclusions: Radica resection is the best treatment for hilar cholangiocarcinoma. The Bismuth type,lymph node metastasis and intraoperative chemotherapy are important influence factors for the prognosis.