Abstract: Objective: To investigate the impact of lymph node metastasis on the prognosis of patients with stage Ⅲ c ovarian carcinoma. Methods: Forty-one patients with stage Ⅲc ovarian cancer from 2003 to 2010 were analyzed retrospectively. All the patients had received line specification surgery and enough cycles of postoperative chemotherapy. Twelve cases had simple lymph node metastasis and 29 intra-abdominal peritoneal tumors 2 cm in diameter without or with lymph node metastasis; 25 cases had no postoperative residual or residual tumors 1 cm in size,and 16 had residual tumors 1 cm in size. Results: The follow-up ranged from 2 to 90 months. The 3-year overall survival( OS) and the 5-year OS in patients with simple lymph node metastasis were 83. 3% and 75. 0% respectively; whereas the 3-year and 5-year OS in cases with intra-abdominal peritoneal tumors 2 cm in diameter without or with lymph node metastasis were 58. 6% and 37. 9%,respectively. The 5-year OS was statistically different( P 0. 05); The patients with no postoperative residual or residual tumors 1 cm in size had significantly better outcomes; and their 3-year OS and 5-year OS were 80. 0% and 56. 0% respectively,which were significantly higher than those with residual tumors 1 cm in size( P 0. 05). Conclusions: Patients of stage Ⅲc ovarian carcinoma with simple lymph node metastasis have a better prognosis than those with intra-abdominal peritoneal tumors 2 cm in diameter. The size of residual tumor is the relevant prognostic factor for patients with stage Ⅲc ovarian carcinoma.