Abstract: Objective: To evaluate the clinical diagnosis value of endoscopic miniprobe sonography( MPS) on prominence lesions of upper gastrointestinal tract. Methods: MPS was performed on 53 prominence lesions of upper gastrointestinal tract of 46 patients. Results: Twenty-two cases were polypuse,12 cases were interstitialoma,4 cases were lipoma,3 cases were heterotopic pancrease,3 cases were cyst,3 cases were external pressure change,2 cases were esophageal varix,2 cases were prolapse of gastric mucosa,1 case was early cancer located in gastric antrum,and 1 case was free of disease. The diagnostic accordance rate of MPS was 100% with the postoperative diagnosis in some lesions. Conclusions: MPS is an accurate,safe,convenient and noninvasive method to diagnose the prominence lesions of upper gastrointestinal tract. It is very important for treatment and evaluating prognosis.