Abstract: Objective: To investigate the etiology and clinical features of hypoglycemic encephalopathy. Methods: The etiology and clinical features of 56 patients with hypoglycemic encephalopathy were retrospectively analysed. Results: Among 56 patients with hypoglycemic encephalopathy,39 cases were related to hypoglycemic drugs,5 cases were caused by the fluoroquinolone drugs,4 cases were caused by insufficient food,3 cases were caused by unknown components and health products,the causes of 3 cases were unknown and 2 cases were complicated with upper respiratory tract infection. The clinical features were disturbance of consciousness,insanity, epilepsy,hemiplegia and choreic movement. Conclusions: The etiology and clinical features of hypoglycemia encephalopathy are complicated and lack of specificity,which is ease to misdiagnose. The hypoglycemic encephalopathy in the patients with central nervous system damage should be taken into account.