Abstract: Objective: To evaluate the clinical value of measuring serum ischemia modified albumin(IMA) using photocolorimetry. Methods: The IMA levels of 46 cases with cTnI positive or electrocardiogram ST session abnormal and 70 healthy subjects were measured through photocolorimetry, analysed by ROC curve, evaluated by the characters of clinical diagnosis and compared with the ultrafiltration albumin cobalt binding test. Results: The intra and inter-assay CV of the precision test results were 1. 3% and 1. 8%, respectively, and the AUC of ROC curve was 0. 995. When the cutoff value was 75 u/ml, the sensitivity, specificity and accuracy of IMA were 97. 8%, 91. 4% and 94. 0%, respectively, and the positive and negative predictive value were 88. 2% and 98. 5%, respectively. The IMA levels detected by two methods had no statistically significance(P ＞ 0. 05) . Conclusions: Compared with the ultrafiltration albumin cobalt binding test, the photocolorimetry to measure the serum IMA is good repeatability and simple and convenient. The high sensitivity and negative predictive value show the high clinical value of IMA for acute coronary syndromes; exclusion diagnosis or thoracalgia diagnosis.