Abstract: Objective: To explore the effects of compound lithospermum ointment in the treatment of middle and small small area burn. Methods: One hundred and twenty patients with burn were randomly divided into control group and observation group( 60 cases each group). The control group and observation group were treated with Mabel burn cream and compound lithospermum ointment, respectively. Results: The cure rate in the observation group( 95. 0%) was higher than that in the control group( 80. 0%)( P 0. 05). The healing time of observation group with shallow Ⅱ wound( 9. 2 3. 1) d was shorter than that in control group( 15. 3 3. 2) d( P 0. 01). No obvious scar in the healing wound in two groups was found. The healing time of observation group with deep Ⅱ wound( 15. 3 3. 2) d was shorter than that in control group( 20 2. 6) d( P 0. 01). Conclusions: Compound lithospermum ointment in the treatment of middle and small small area burn is high cure rate and short healing time.