Abstract: Objective: To study the therapeutic effect of Yiqihuoxue decoctionin in treatment of carotid arteriosclerosis plaque in diabetic patients. Methods: Sixty cases of diabetes with carotid arteriosclerosis plaque were randomly divided into treatment group and control group,30 cases in each. Both groups received the routine western medicine therapy,and the treatment group were given yiqihuoxue decoction orally twice a day,200 ml each time in addition,8 weeks as a circle. The plaque regression rate,the change of haemorheology and the blood glucose were recorded. Results: The plaque regression rate of the treatment group was significantly higher than that of the control( P 0. 01); and the change of haemorheology improved obviously in the treatment group( P 0. 01). Conclusions: Yiqihuoxue decoction is effective in treatment of the carotid arteriosclerosis plaque in diabetics.