Abstract: Objective: To investigate the application value of virtual touch tissue quantification( VTQ) technique in liver damage detection of hepatolenticular dageneration( HD) patient. Methods: One hundred fourty-six HD patients were detected using ultrasound and VTQ technique,their liver ultrasonographic manifestations were classified,and the VTQ value of two kinds of liver sonograms were compared. Results: The VTQ value of 146 HD patients was 1. 14 to 3. 71 m / s. The difference of VTQ value in two kinds of liver sonograms had statistic significance( P 0. 01). The VTQ value of light liver disease HD patients with fatty infiltration type and glinting echogemic dots type sonogram were lower than those in patients with the tree like type,rock stratum type and nodular type sonograms( P 0. 01). The VTQ value of patients with nodular type sonogram was higher than that in patients with tree like type and rock stratum type sonograms( P 0. 01),the VTQ value difference between tree like type and rock stratum type patients has no statistic significance( P 0. 05). Conclusions: VTQ technique can objectively evaluate the liver damage degree of HD patient.