Abstract: Objective: To investigate the type distribution of human papillomavirus( HPV) in patients with condyloma acuminatum( CA). Methods: The HPV DNA( high-risk and low-risk type) of lesion and secretion of condyloma acuminatum in CA patients were detected by fluorescent quantitative polymerase chain reaction. Results: The positive detection rates of HPV in 110 CA patients were 100%. Low-risk,high-risk and high and low-risk compound infection in all CA patients were 64. 55%,14. 54% and 20. 91%,respectively. The detection rate differences of HPV in different gender and age had no statistical significance( P 0. 05). Conclusions: The low-risk HPV infection is mostly and high-risk HPV infection is relatively high in CA patients. It suggests that the prevention and treatment of genital tumor should be strengthened.