Abstract: Objective: To develop the best advantages of blended learning,contruct the medical genetics online course and combine make the network course and the traditional classroom teaching an organic unity. Methods: The medical genetics online course was constructed by useful software. Results: Medical genetics online course based on blended learning was achieved. Conclusions: The teaching environment and conditions of universities were greatly changed by information technology,medical genetics online course based on blended learning can combine the traditional classroom teaching and online learning into a unity,which can run fully the teaching characteristics and advantages.