Abstract: Objective: To investigate the effects of Xuesaitong injection on coagulation function of patients undergoing laparoscopic cholecystectomy(LC).Methods: Fifty patients with LC were randomly divided into control group and Xuesaitong group(25 cases each group).The control group were treated with conventional anti-infection combined with transfusion.The Xuesaitong group were treated with Xuesaitong based on the control group treatment by intravenous drip at 1 day after surgery once daily for 6 days.The levels of prothrombin time (PT)and activeated partial thromboplastin time (APTT)of all patients were measured in the preoperative and postoperative 3,5 and 7 days.Results: There were not significant difference in the levels of PT,APTT and international normalized ratio(INR)between the two groups before the operation(P ＞ 0.05).There were significant difference in the levels of PT between the two groups at 7 days after operation(P＜0.01).There were not significant difference in the levels of PT,APTT and INR of each group at different time points before and after the operation(P ＞ 0.05).Conclusions: Xuesaitong injection can obviously improve the state.