解华, 张华满, 杨跃莲. 高强度超声聚焦刀联合吉西他滨治疗老年人晚期胰腺癌26例[J]. 蚌埠医学院学报, 2012, 36(12): 1474-1475.
    引用本文: 解华, 张华满, 杨跃莲. 高强度超声聚焦刀联合吉西他滨治疗老年人晚期胰腺癌26例[J]. 蚌埠医学院学报, 2012, 36(12): 1474-1475.
    XIE Hua, ZHANG Hua-man, YANG Yue-lian. Treatment of 26 older pancreatic cancer late cases with high intensity focused ultrasound combined with gemcitabine[J]. Journal of Bengbu Medical College, 2012, 36(12): 1474-1475.
    Citation: XIE Hua, ZHANG Hua-man, YANG Yue-lian. Treatment of 26 older pancreatic cancer late cases with high intensity focused ultrasound combined with gemcitabine[J]. Journal of Bengbu Medical College, 2012, 36(12): 1474-1475.

    高强度超声聚焦刀联合吉西他滨治疗老年人晚期胰腺癌26例

    Treatment of 26 older pancreatic cancer late cases with high intensity focused ultrasound combined with gemcitabine

    • 摘要: 目的: 观察高强度超声聚焦刀(high intensity focused ultrasound,HIFU)联合吉西他滨治疗老年人晚期胰腺癌的近期疗效及不良反应。方法: 将26例老年人晚期胰腺癌患者随机分成2组,各13例,均给予HIFU治疗,观察组在HIFU治疗过程中给予吉西他滨化疗,对照组未给予化疗,观察2组治疗2个疗程后的临床受益率、肿瘤客观疗效、CA199水平的变化及不良反应。结果: 观察组与对照组的有效率分别为69.23%及23.08%,对CA199水平下降分别为84.62%及38.46%,差异均有统计学意义(P=0.047和P=0.041);观察组的临床受益率为69.23%,对照组为38.46%,差异无统计学意义(P=0.238);2组不良反应均较轻。结论: HIFU联合化疗能控制肿瘤生长,提高患者生活质量,降低CA199的浓度,且不良反应轻。

       

      Abstract: Objective: To evaluate the effectiveness and toxicity of high intensity focused ultrasound (HIFU)combined with gemcitabine in treatment for older pancreatic cancer.Methods: Twenty-six older pancreatic cancer late cases from our hospital were divided into two groups,all patients were given HIFU treatment,the observation group were added gemcitabine single-agent chemotherapy, the control group did not received chemotherapy.Clinical benefit response,clinical curative effect, the concentration of CA199 and side-effect were observed after 2 treatment course.Results: The effective rates of the observation group and control group were 69.23% and 23.08%, respectively and the concentration of CA199 of both the observation group and control group dropped to 84.62% and 38.46%, respectively.The differences had statistical significance (P = 0.047 and P = 0.041).The clinical benefit responses of the observation group and control group were 69.23% and 38.46%,respectively, the difference had not statistical significance(P = 0.238),and their side-effects were not serious.Conclusions: HIFU combined with chemotherapy can control tumor growth, improve the quality of life, reduce the CA199 concentration and cause light side-effect for patients.

       

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