Abstract: Objective: To study the clinical value of detecting serum retinol-binding protein( RBP),pre-albumin( PA),albumin( ALB) and cholinesterase( CHE) for patients with liver cirrhosis. Methods: Immunotransmission turbidity,end-point method, Bromocreosol creosol green method and Butyrylthiocholine / Potassium ferricyanide method were used to detect the serum RBP,PA,ALB and CHE levels in 81 cases of liver cirrhosis of various degrees( according to the Child-pugh grading); and 35 healthy persons acted as control. Results: Compared with the control group,the levels of serum RBP,PA,ALB and CHE in the liver cirrhosis group were decreased significantly( P 0. 01). In patients with liver cirrhosis,the levels of serum RBP,PA,ALB and CHE were decreased according to the Child-pugh grading with marked differences( P 0. 01). Conclusions: Combination detection of serum RBP,PA,ALB and CHE could effectively monitor the degree of liver damage,which has great reference value in evaluating the pathogenetic condition, curative effect and prognosis of patients with liver cirrhosis.