食管癌常规放疗、后程适形放疗和全程适形放疗比较

程元芝; 张广军; 王姗

食管癌常规放疗、后程适形放疗和全程适形放疗比较

Comparison of effect of routine radiotherapy,3 -dimensional conformal radiotherapy(3DCRT) of late half course and 3DCRT in esophageal carcinoma

摘要

摘要: 目的: 评价常规放疗、后程三维适形放疗(3DCRT)和全程3DCRT在食管癌放射治疗中的近期疗效和放射反应。方法: 将50例食管癌患者分为3组,常规放疗组13例,先常规放疗后程3DCRT组17例,全程3DCRT组20例。处方剂量50～70 Gy,分割剂量2 Gy,1次/天,5次/周。结果: 常规放疗组、后程3DCRT组及全程3DCRT组有效率分别为76.9%、88.2%和95.0%,差异无统计学意义(P＞0.05);1年局部控制率分别为53.8%、88.2%、90.0%,1年生存率分别为53.8%、94.1%、90.0%,差异均有统计学意义(P＜0.05和P＜0.01)。结论: 食管癌3DCRT安全有效,全程3DCRT和后程3DCRT预后好于常规放疗,急性放射损伤较轻。

Abstract: Objective: To evaluate the efficiency and radioreactions of routine radiotherapy,3-dimensional conformal radiotherapy (3DCRT)of late half course and 3DCRT in esophageal cancer.Methods: Fifty patients with esophageal cancer were divided into three groups.Thirteen cases were treated with routine radiotherapy, 17 cases were treated with routine radiotherapy combined with 3DCRT of late half course and 20 cases were treated with 3DCRT.The prescribed and fractionation dose were from 50 to 70 Gy and 2 Gy a time with once a day(5 times a week), respectively.Results: The effective rates of routine radiotherapy,3DCRT of late half course and 3DCRT were 76.9%, 88.2% and 95.0%, respectively,which differences were not statistically significant(P ＞ 0.05).The local control and survival rates of 1-year of routine radiotherapy,3DCRT of late half course and 3DCRT group were 53.8%,88.2%,90.0% and 53.8%, 94.1%, 90.0%, respectively,which differences were statistically significant(P＜0.05 and P＜0.01).Conclusions: 3DCRT is effective and safe in the treatment of esophageal cancer.The prognosis and acute radiation injury of 3DCRT of late half course and 3DCRT are better and lighter than that of routine radiotherapy group.

HTML全文

参考文献(11)

施引文献

资源附件(0)