Abstract: Objective: To explore the causes,treatment strategies and prevention measures of the complications in permanent cardiac pacemaker implantation. Methods: The data of 121 patients with permanent cardiac pacemaker implantation were retrospectively analyzed. One hundred and twenty-one patients included 53 cases of athological sinoatrial node syndrome,23 cases of Ⅲ degree atrioventricular block,16 cases of Ⅱ degree atrioventricular block,15 cases of pathological sinoatrial node syndrome complicated with atrioventricular block and 14 cases of persistent atrial fibrillation complicated with slow ventricular rate or more than 3 second long interval. Results: The complications occurred in 15 cases,including 1 case of pneumothorax,5 cases of capsule bag hemorrhage and hematoma,5 cases of capsule bag infection( 1 cases complicated with capsule bag hematoma),2 cases of electrode dislocation,1 case of wire electrode connection fail,1 case of pacemaker syndrome and 1 case of upper extremity deep vein thrombosis. The complications of 15 cases cured or alleviated after the corresponding treatment. Conclusions: Thoroughly understanding of the common complications, paying attention to preoperative prevention,standardizing operation procedure,strengthening following up and the education of pacemaker knowledge and early discovering and handling complication can reduce the complications.