Abstract: Objective: To investigate the glucolipid metabolic features of type 2 diabetes mellitus( T2DM) patients with or without central obesity,and discuss the relationship between central obesity and large vessel complication. Methods: Sixty-six patients with T2DM were divided into obesity group and non-obesity group according to their waist circumference. The glucolipid metabolic features and large vessel complication in two groups were analyzed. Results: The insulin resistance index and the occurrence rate of large vessel complication in obesity group were higher than those in non-obesity group( P 0. 01). Conclusions: The severe insulin resistance and high occurrence rate of metabolic syndrome in T2DM patients with central obesity are found,which can lead to the high occurrence rate of large vessel complications.