Abstract: Objective: To explore the application effects of optimization calm on the patients with cerebral hemorrhage. Methods: Thirty-nine patients with cerebral hemorrhage were randomly divided into the observation group( 20 cases) and control group( 19 cases). The control group were calmed by simple daily waking up plan. The observation group were calmed by procedural sedation combined with daily waking up. The application time of mechanical ventilation,the complication rates of mechanical ventilation,the man-machine confrontation,the incidence of the tube accidental taking off,and the change of MAP and consciousness recovery of two groups were compared. Results: There were not statistical significance in the application time of mechanical rentilation and complication rates of mechanical ventilation between two groups( P 0. 05). Compared with the control group,the patients' MAP and the consciousness recovery were good in the observation group. Conclusions: Both the optimization calm and simple daily waking up plan can prevent unconscious behavior interference treatment. The optimization calm can reduce the occurrence of postoperative complications in patients with cerebral hemorrhage,and is more conducive to the recovery of consciousness.