手术治疗肺肉瘤样癌22例预后影响因素分析
Long-term prognosis factors for patients having received surgery for lung sarcomatoid carcinoma:an analysis of 22 cases
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摘要: 目的:探讨手术治疗肺肉瘤样癌(LSC)后长期生存率及预后影响因素。方法:对22例LSC均行根治性手术治疗,其中肺叶切除18例,全肺切除3例,肺叶切除合并心包部分切除1例。术后评价可能的预后因素对长期生存的影响。结果:术后1、3、5年总生存率分别为63.6%、18.2%和4.5%;单因素分析显示,p-TNM分期和N分期均是影响患者术后长期生存的主要因素(P0.05);多因素分析显示,年龄、p-TNM分期和病理分化程度均是影响预后的独立危险因素(P0.01)。结论:LSC治疗效果不佳,手术后5年生存率极低。年龄、p-TNM分期和病理分化程度均是影响LSC手术预后的主要因素。Abstract: Objective:To explore the factors influencing the survival and long-term prognosis of patients having undergone surgical operation for lung sarcomatoid carcinoma.Methods:The clinical data of 22 cases who had received surgical treatment for lung sarcomatoid carcinoma were retrospectively reviewed.The potential prognostic factors were analyzed by COX' s proportional hazard regression model.Results:The overall 1,3 and 5-year survival rates were 63.6%,18.2% and 4.5%,respectively.p-TNM stage and N status were valued as prognostic factors in COX univariate analysis(P 0.05).Age,p-TNM stage and type of pathology were identified as independent prognostic factors by COX multivariate analysis (P 0.01).Conclusions:There is no effective therapy for lung sarcomatoid carcinoma and the 5-year survival rate is quite low.Age,p-TNM stage and type of pathology are the crucial prognostic factors for patients with lung sarcomatoid carcinoma.
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